We present a straightforward and comprehensive approach for DNA methylation analysis in
mammalian genomes. The methylated-CpG island recovery assay (MIRA), which is based …

DNA methylation patterns are often altered in human cancer and aberrant methylation is
considered a hallmark of malignant transformation. Several methods have been developed …

BACKGROUND Aberrant DNA methylation of the CpG islands for cancer‐related genes is
among the earliest and most frequent alterations in cancer and may be useful for diagnosing …

Aberrant DNA methylation is an important event in carcinogenesis. Of the various regions of
a gene that can be methylated in cancers, the promoter is the most important for the …

De novo methylation of CpG islands is a common phenomenon in human cancer, but the
mechanisms of cancer-associated DNA methylation are not known. We have used tiling …

The genome of epithelial tumors is characterized by numerous chromosomal aberrations,
DNA base sequence changes, and epigenetic abnormalities. The epigenome of cancer cells …

An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms.
The lack of high-throughput methods with high specificity and sensitivity to detect changes in …

DNA methylation is part of the epigenetic gene regulation complex, which is relevant for the
pathogenesis of cancer. We performed a genome-wide search for methylated CpG islands …

DNA methylation is an epigenetic modification involved in both normal developmental
processes and disease states through the modulation of gene expression and the …

DNA methylation has a role in the regulation of gene expression during normal mammalian
development but can also mediate epigenetic silencing of CpG island genes in cancer and …