Repression of transcription from densely methylated genes can be mediated by the methyl‐
CpG binding protein MeCP‐1 (Boyes and Bird, 1991). Here we have investigated the effect …

We have studied the mechanism by which DNA methyiation inhibits transcription both in ceil-
free nuclear extracts and in the living ceil. Repression of transcription in vitro for four different …

An important consequence of CpG methylation is the local silencing of gene expression. In
part this can be mediated by direct interference of methylation with the binding of …

CpG methylation is known to suppress transcription. This repression is generally thought to
be related to alterations of chromatin structure that are specified by the methylation. The …

Several lines of evidence strongly indicate that methylation of cytosine residues within CpG
dinucleotides are implicated in the regulation of gene expression in eukaryotes. Transfection …

The effects of DNA methylation on transcription and chromatin structure require that nuclear
factors be able to distinguish methylated and nonmethylated DNA. We describe a nMhyWpG …

Methylation ofcytosine residues in mammalian genomes is associated with transcriptional
repression and inactive chromatin. It has been shown that methylation of DNA is essential …

Since its discovery, methylation of DNA in mammalian cells has been correlated with
transcriptional repression and with specialized chromatin structures. Recently, considerable …

Processes that regulate gene transcription are directly under the influence of the genome
organization. The epigenome contains additional information that is not brought by DNA …

Methylated DNA in vertebrates is associated with transcriptional repression and inactive
chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically …