INTRODUCTION Nearly all cells in the human body share the same primary genome
sequence consisting of four nucleotide bases. One of the bases, cytosine, is commonly …

DNA methylation: A molecular lock: Current Biology Skip to Main Content Advertisement Current
Biology This journal offers authors two options (open access or subscription) to publish research …

DNA methylase activity in the nuclei of somatic cells arrested at G0 increased markedly
when the cells were subjected to a mitogenic stimulus. Treatment of mouse splenocytes with …

Methylation of CpG islands is associated with transcriptional repression and, in cancer,
leads to the abnormal silencing of tumor suppressor genes. We have developed a novel …

The most common modification of DNA in plant cells is methylation of cytosine residues at
carbon 5. In contrast to mammalian cells in which 3–8% of cytosine residues are methylated …

MeCP2 is an abundant mammalian protein that binds methylated CpG (mCpG) sequences
within double-stranded DNA, represses transcription by recruiting histone deacetylases, and …

DNA methylation plays an important role in mammalian development and correlates with
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

MBD1, a member of the methyl-CpG-binding domain family of proteins, has been reported to
repress transcription of methylated and unmethylated promoters. As some MBD1 isoforms …

A correlation between DNA methylation and transcriptional silencing has existed for many
years. Recently, substantial progress has been reported in the search for proteins that …