DNA methylation patterns are frequently altered in cancer cells as compared to normal cells.
A large body of research associates these DNA methylation aberrations with cancer …

Targeting DNA methylation for cancer therapy has had a rocky history. The first reports on
DNA methylation changes in cancer described global loss of methylation, which has been …

Cancer growth and metastasis requires reprogramming of the expression of multiple genes.
The epigenome, which is comprised of chromatin and the patterns of DNA methylation, sets …

DNA methylation is an epigenetic modification that contributes to essential biological
processes such as retrotransposon silencing, cell differentiation, genomic imprinting and X …

One of the hallmarks of cancer is aberrant DNA methylation, which is associated with
abnormal gene expression. Both hypermethylation and silencing of tumour suppressor …

Genetic alterations, including DNA sequence and copy number alterations, have been
characterized in human cancers for over several decades. However, it is becoming …

The epigenome, which is comprised of chromatin and its associated proteins and the
patterns of covalent modification of DNA by methylation, sets up and maintains gene …

The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale international …

Methylation of DNA is known to be an important mechanism of gene regulation. A hallmark
of cancer is the deregulation of the DNA methylation machinery and aberrant DNA …

DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic
silencing of cancer-related genes. Since the relationship between aberrant DNA methylation …