Estimation of reference curves for the urinary steroid metabolome in the first year of life in healthy children: tracing the complexity of human postnatal steroidogenesis
NA Dhayat, AC Frey, BM Frey, CH d'Uscio… - The Journal of steroid …, 2015 - Elsevier
Context Complex steroid disorders such as P450 oxidoreductase deficiency or apparent
cortisone reductase deficiency may be recognized by steroid profiling using …
cortisone reductase deficiency may be recognized by steroid profiling using …
The evolution of methods for urinary steroid metabolomics in clinical investigations particularly in childhood
JW Honour, E Conway, R Hodkinson, F Lam - The Journal of steroid …, 2018 - Elsevier
The metabolites of cortisol, and the intermediates in the pathways from cholesterol to cortisol
and the adrenal sex steroids can be analysed in a single separation of steroids by gas …
and the adrenal sex steroids can be analysed in a single separation of steroids by gas …
Reduced activity of 11β-hydroxylase accounts for elevated 17α-hydroxyprogesterone in preterms
C Kamrath, MF Hartmann, C Boettcher… - The Journal of Pediatrics, 2014 - Elsevier
Objective To characterize the urinary steroid metabolome of neonates and infants born
either at term or preterm. Study design We retrospectively analyzed urinary steroid hormone …
either at term or preterm. Study design We retrospectively analyzed urinary steroid hormone …
A guide to understanding the steroid pathway: new insights and diagnostic implications
RF Greaves, G Jevalikar, JK Hewitt, MR Zacharin - Clinical biochemistry, 2014 - Elsevier
Steroid analysis has always been complicated requiring a clear understanding of both the
clinical and analytical aspects in order to accurately interpret results. The literature relating …
clinical and analytical aspects in order to accurately interpret results. The literature relating …
The androgen metabolome of preterm infants reflects fetal adrenal gland involution
CE Flück, T Kuiri-Hänninen… - The Journal of …, 2022 - academic.oup.com
Context The human adrenal cortex changes with fetal-neonatal transition from the fetal to the
adult organ, accompanied by changes in the steroid metabolome. Objective As it is unclear …
adult organ, accompanied by changes in the steroid metabolome. Objective As it is unclear …
Androgen biosynthesis during minipuberty favors the backdoor pathway over the classic pathway: Insights into enzyme activities and steroid fluxes in healthy infants …
NA Dhayat, B Dick, BM Frey, CH d'Uscio, B Vogt… - The Journal of steroid …, 2017 - Elsevier
The steroid profile changes dramatically from prenatal to postnatal life. Recently, a novel
backdoor pathway for androgen biosynthesis has been discovered. However, its role …
backdoor pathway for androgen biosynthesis has been discovered. However, its role …
Steroid biochemistry
Accurate analysis of steroid hormones represents an essential part in the evaluation of a
patient with disorders or differences in sex development. Analytical methods based on mass …
patient with disorders or differences in sex development. Analytical methods based on mass …
Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis
Objective Urinary steroid metabolomics by GC-MS is an established method in both clinical
and research settings to describe steroidogenic disorders. However, population-based …
and research settings to describe steroidogenic disorders. However, population-based …
Steroid metabolome in fetal and maternal body fluids in human late pregnancy
M Hill, A Pařízek, D Cibula, R Kancheva… - The Journal of steroid …, 2010 - Elsevier
Despite the extensive research during the last six decades the fundamental questions
concerning the role of steroids in the initiation of human parturition and origin and function of …
concerning the role of steroids in the initiation of human parturition and origin and function of …
Steroid metabolomic disease signature of nonsyndromic childhood obesity
A Gawlik, M Shmoish, MF Hartmann… - The Journal of …, 2016 - academic.oup.com
Context: The profile of urinary steroids as measured by gas chromatography-mass
spectrometry defines a subject's “steroidal fingerprint.” Objective: Here, we clustered …
spectrometry defines a subject's “steroidal fingerprint.” Objective: Here, we clustered …