Most of the studies characterizing DNA methylation patterns have been restricted to
particular genomic loci in a limited number of human samples and pathological conditions …

Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …

Genomic DNA methylation profiles exhibit substantial variation within the human population,
with important functional implications for gene regulation. So far little is known about the …

DNA methylation is the most studied epigenetic mark and CpG methylation is central to
many biological processes and human diseases. Since cancer has highlighted the …

Abnormalities of genomic methylation patterns are lethal or cause disease, but the cues that
normally designate CpG dinucleotides for methylation are poorly understood. We have …

As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …

Cytosine in CpG dinucleotides is frequently found to be methylated in the DNA of higher
eukaryotes and differential methylation has been proposed to be a key element in the …

There are over 28 million CpG sites in the human genome. Assessing the methylation status
of each of these sites will be required to understand fully the role of DNA methylation in …

Background Epigenetic polymorphisms are a potential source of human diversity, but their
frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an …

Background DNA methylation, which mainly occurs at CpG dinucleotides, is a dynamic
epigenetic regulation mechanism in most eukaryotic genomes. It is already known that …