The zebrafish has become a mainstream vertebrate model that is relevant for many
disciplines of scientific study. Zebrafish are especially well suited for forward genetic …

Mouse embryonic stem (ES) cell lines are routinely used to introduce targeted mutations into
the genome, providing an efficient method to study gene function. Application of similar gene …

The zebrafish is an excellent genetic and developmental model system used to study
biology and disease. While the zebrafish model is associated with high fecundity, its …

Heterozygosity in diploid eukaryotes often makes genetic studies cumbersome. Methods
that produce viable homozygous diploid offspring directly from heterozygous females allow …

One of the most powerful tools used to gain insight into complex developmental processes is
the analysis of chimeric embryos. A chimera is defined as an organism that contains cells …

Most current methods for genotyping zebrafish embryos require sacrifice or raising the
animal to at least 1 month of age for fin amputation. These limitations restrict the use of …

The zebrafish has become a popular model system for genetic studies of vertebrate
development. Zebrafish are amenable to such studies because the generation time of …

Over the past decade, the zebrafish has become an important model organism for biological
research. In recent years, more than 1800 zebrafish mutants have been identified, providing …

Due to its prolific reproduction and the external development of the transparent embryo, the
zebrafish is the prime model for genetic and developmental studies, as well as research in …

The zebrafish is an established model for the genetic analysis of vertebrate development.
Forward-genetic screens have generated thousands of mutations, and antisense-based …