Background Epigenetic mechanisms may play a major role in the biological embedding of
early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release …

DNA methylation of the FKBP5 gene is assumed to alter FKBP5 expression and hence the
synthesis of the FK506 binding protein 51, a central element of a genomic negative …

Prior studies identified DNA methylation (DNAM) changes in a regulatory region within the
FK506 binding protein 5 (FKBP5) gene as a crucial mediator of long-term negative health …

Background Subclinical hypercortisolism and hypothalamic-pituitary-adrenal (HPA) axis
dysfunction are associated with type 2 diabetes (T2DM), cardiovascular disease, and …

While biological alterations associated with childhood maltreatment (CM) have been found
in affected individuals, it remains unknown to what degree these alterations are biologically …

Background Epigenetic studies that utilize peripheral tissues to identify molecular substrates
of neuropsychiatric disorders rely on the assumption that disease-relevant, cellular …

Differential DNA methylation of the hypothalamic‐pituitary‐adrenal axis related gene FKBP5
has recently been shown to be associated with varying response to environmental …

Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …

Humanized mouse models can be used to explore human gene regulatory elements (REs),
which frequently lie in non-coding and less conserved genomic regions. Epigenetic …

Rationale Given the contribution of cortisol dysregulation to neuropsychiatric and metabolic
disorders, it is important to be able to accurately compute glucocorticoid burden, a measure …