Theodore Boveri, eminent German pathologist, observed aneuploidy in cancer cells more
than a century ago and suggested that cancer cells derived from a single progenitor cell that …

Cancers have a clonal origin, yet their chromosomes and genes are non‐clonal or
heterogeneous due to an inherent genomic instability. However, the cause of this genomic …

The role of aneuploidy in carcinogenesis has long been debated. We argue here that
aneuploid genomes are naturally more susceptible to the types of chromosome …

It has been difficult to find a common cause for the many and complex phenotypes of cancer
such as dedifferentiation, invasiveness, abnormal morphology, growth rate and metabolism …

Numeric aberrations in chromosomes, referred to as aneuploidy, is commonly observed in
human cancer. Whether aneuploidy is a cause or consequence of cancer has long been …

Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …

Most tumours arise through clonal selection and waves of expansion of a somatic cell that
has acquired genetic alterations in essential genes either controlling cell death or cell …

Aneuploidy has a paradoxical effect on cell proliferation. In all normal cells analyzed to date,
aneuploidy has been found to decrease the rate of cell proliferation. Yet, aneuploidy is also …

A change in chromosome number that is not the exact multiple of the haploid karyotype is
known as aneuploidy. This condition interferes with growth and development of an organism …

Genomic instability is often considered a hallmark of cancer. However, it remains unclear
whether chromosomal disorganization is most frequently a cause or a consequence of …