Background High-grade soft tissue sarcomas are a heterogeneous, complex group of
aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue …

Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some …

The aberrant methylation of promoter CpG islands is known to be a major inactivation
mechanism of tumor-related genes. To determine the clinicopathological significance of …

Purpose Pediatric sarcomas provide a unique diagnostic challenge. There is considerable
morphologic overlap between entities, increasing the importance of molecular studies in the …

Rhabdomyosarcoma is the most common soft-tissue sarcoma in children. While cytogenetic
abnormalities have been well characterized in this disease, aberrant epigenetic events such …

Aberrant methylation of genomic DNA has been reported in many cancers. Specific DNA
methylation patterns have been shown to provide clinically useful prognostic information …

Genetic and epigenetic changes contribute to deregulation of gene expression and
development of human cancer. Changes in DNA methylation are key epigenetic factors …

Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …

Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …

The identification of optimal methylation biomarkers to achieve maximum diagnostic ability
remains a challenge. The present study aimed to elucidate the potential molecular …