DNA methylation is a major determinant in the epigenetic silencing of genes. The
mechanisms underlying the targeting of DNA methylation and the subsequent repression of …

The role of DNA methylation and recently discovered hydroxymethylation in the function of
the human epigenome is currently one of the hottest topics in the life sciences. Progress in …

Epigenetic regulation in eukaryotic and mammalian systems is a complex and emerging
field of study. While histone modifications create an open chromatin conformation allowing …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …

Genes constitute only a small proportion of the mammalian genome, the majority of which is
composed of non-genic repetitive elements including interspersed repeats and satellites. A …

The epigenome, which comprises chromatin, associated proteins, and the pattern of
covalent modification of DNA by methylation, sets up and maintains gene expression …

Epigenetic regulation is the mechanism by which gene function is selectively activated or
inactivated in the cells. It provides higher-ordered and more specified genetic information …

DNA methylation, as an epigenetic mechanism, occurs by adding a methyl group of
cytosines in position 5 by DNA methyltransferases and has essential roles in cellular …

To date, nearly 100 autoimmune diseases have been an area of focus, and these diseases
bring health challenges to approximately 5% of the population worldwide. As a type of …