Tumorigenesis begins with the disregulated growth of an abnormal cell that has acquired
the ability to divide more rapidly than its normal counterparts (Nowell, PC (1976) Science …

It is frequently assumed that DNA-damaging agents are carcinogenic because they induce
mutations. However, another strong possibility is that the damage leads to heritable changes …

There is considerable interest in the role that DNA methylation (5-methylcytosine [5MeC]
content of DNA) plays in both normal development (Razin and Kafri, 1994) and …

Methylcytosine (5mC) in DNA is produced by post-synthetic modification of cytosine
residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a …

Changes in the pattern of DNA methylation have been a consistent finding in cancer cells.
The mostly descriptive nature of these studies and the fact that both hypo-and …

Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …

▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

Cancer is often viewed as a genetic process in which the developing cancer cell acquires
successive mutational lesions that each provide the cell with a growth or survival advantage …

It has become clear over the last few years that DNA methylation is essential for normal
embryonic development and that alterations in DNA methylation are very common in cancer …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …