Mammalian development requires cytosine methylation, a heritable epigenetic mark of
cellular memory believed to maintain a cell's unique gene expression pattern. However, it …

Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet
the rules that govern methylation patterns remain largely elusive. To gain insights into this …

Cytosine DNA methylation is essential for mammalian development but understanding of its
spatiotemporal distribution in the developing embryo remains limited,. Here, as part of the …

DNA cytosine methylation is a central epigenetic modification that has essential roles in
cellular processes including genome regulation, development and disease. Here we …

DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …

DNA methylation patterns are set up in a relatively fixed programmed manner during normal
embryonic development and are then stably maintained. Using genome-wide analysis, we …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …

DNA methylation is extensively reprogrammed during the early phases of mammalian
development, yet genomic targets of this process are largely unknown. We optimized …

DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …