Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery

M Trøseid, JR Hov, TK Nestvold… - … syndrome and related …, 2016 - liebertpub.com
Abstract Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from
trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary …

Effect of vegan fecal microbiota transplantation on carnitine‐and choline‐derived trimethylamine‐N‐oxide production and vascular inflammation in patients with …

LP Smits, RS Kootte, E Levin, A Prodan… - Journal of the …, 2018 - Am Heart Assoc
Background Intestinal microbiota have been found to be linked to cardiovascular disease via
conversion of the dietary compounds choline and carnitine to the atherogenic metabolite …

[HTML][HTML] Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal …

BC Fu, MAJ Hullar, TW Randolph, AA Franke… - The American journal of …, 2020 - Elsevier
ABSTRACT Background Trimethylamine N-oxide (TMAO), a compound derived from diet
and metabolism by the gut microbiome, has been associated with several chronic diseases …

[HTML][HTML] Effect of Choline Forms and Gut Microbiota Composition on Trimethylamine-N-Oxide Response in Healthy Men

CE Cho, NDJ Aardema, ML Bunnell, DP Larson… - Nutrients, 2020 - mdpi.com
Background: Trimethylamine-N-oxide (TMAO), a choline-derived gut microbiota-dependent
metabolite, is a newly recognized risk marker for cardiovascular disease. We sought to …

[HTML][HTML] The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases

J Zhen, Z Zhou, M He, HX Han, EH Lv… - Frontiers in …, 2023 - frontiersin.org
Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women

Z Wang, N Bergeron, BS Levison, XS Li… - European heart …, 2019 - academic.oup.com
Aims Carnitine and choline are major nutrient precursors for gut microbiota-dependent
generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO). We performed …

Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation

J Kuka, E Liepinsh, M Makrecka-Kuka, J Liepins… - Life sciences, 2014 - Elsevier
Abstract Aims Trimethylamine-N-oxide (TMAO) is produced in host liver from trimethylamine
(TMA). TMAO and TMA share common dietary quaternary amine precursors, carnitine and …

Interplay between diet and gut microbiome, and circulating concentrations of trimethylamine N-oxide: findings from a longitudinal cohort of US men

J Li, Y Li, KL Ivey, DD Wang, JE Wilkinson, A Franke… - Gut, 2022 - gut.bmj.com
Objectives Gut-produced trimethylamine N-oxide (TMAO) is postulated as a possible link
between red meat intake and poor cardiometabolic health. We investigated whether gut …

Trimethylamine/trimethylamine-N-oxide as a key between diet and cardiovascular diseases

S He, H Jiang, C Zhuo, W Jiang - Cardiovascular Toxicology, 2021 - Springer
Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of
choline, betaine or l-carnitine and could be further converted to Trimethylamine-N-oxide …

[HTML][HTML] The use of an in-vitro batch fermentation (human colon) model for investigating mechanisms of TMA production from choline, l-carnitine and related …

P Day-Walsh, E Shehata, S Saha, GM Savva… - European Journal of …, 2021 - Springer
Purpose Plasma trimethylamine-N-oxide (TMAO) levels have been shown to correlate with
increased risk of metabolic diseases including cardiovascular diseases. TMAO exposure …