The gut microbiome metabolizes choline and carnitine to release trimethylamine (TMA),
which subsequently undergoes hepatic conversion to trimethylamine N-oxide (TMAO) …

The gut microbiota plays an obligatory role in the metabolism of nutrients containing
trimethylamine moieties, such as l-carnitine and choline, leading to the production of the …

Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of
choline results in the production of trimethylamine (TMA), which upon absorption by the host …

Background Dietary nutrient intake and its metabolism by the gut microbiome have recently
been implicated in cardiovascular disease (CVD) risk. In particular, trimethylamine N-oxide …

Abstract Plasma Trimethylamine-N-oxide (TMAO), a gut microbiota metabolite from dietary
phosphatidylcholine, is mechanistically linked to cardiovascular disease (CVD) and adverse …

Recent evidence, including massive gene-expression analysis and a wide-variety of other
multi-omics approaches, demonstrates an interplay between gut microbiota and the …

It has been suggested that trimethylamine N‐oxide (TMAO) is associated with increased risk
of diabetes and cardiovascular disease (CVD) morbidity and mortality. However, it is not …

Objective The gut microbiota-derived metabolite, trimethylamine N-oxide (TMAO) plays an
important role in cardiovascular disease (CVD). The fasting plasma TMAO was shown as a …

Trimethylamine N-oxide (TMAO) is a biologically active molecule and is a putative promoter
of chronic diseases including atherosclerosis in humans. Host intestinal bacteria produce its …

We critically review potential involvement of trimethylamine N-oxide (TMAO) as a link
between diet, the gut microbiota and CVD. Generated primarily from dietary choline and …