Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target

S Yang, X Li, F Yang, R Zhao, X Pan, J Liang… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in
developed countries, and atherosclerosis (AS) is the common pathological basis of many …

Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus

WHW Tang, Z Wang, XS Li, Y Fan, DS Li, Y Wu… - Clinical …, 2017 - academic.oup.com
BACKGROUND Recent studies show a mechanistic link between intestinal microbial
metabolism of dietary phosphatidylcholine and coronary artery disease pathogenesis …

Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria

SA Winther, JC Øllgaard, TW Hansen… - PLoS …, 2021 - journals.plos.org
Aims The trimethylamine N-oxide (TMAO) pathway is related to intestinal microbiota and has
been associated to risk of cardiovascular disease (CVD). We investigated associations …

Microbial trimethylamine-N-oxide as a disease marker: something fishy?

B Landfald, J Valeur, A Berstad… - Microbial ecology in health …, 2017 - Taylor & Francis
Production of trimethylamine-N-oxide (TMAO) via the gut microbiota has recently been
proposed as an important pathophysiological mechanism linking ingestion of 'unhealthy …

Circulating trimethylamine N-oxide is associated with increased risk of cardiovascular mortality in type-2 diabetes: Results from a Dutch Diabetes Cohort (ZODIAC-59)

JL Flores-Guerrero, PR van Dijk, MA Connelly… - Journal of Clinical …, 2021 - mdpi.com
Trimethylamine N-oxide (TMAO), a novel cardiovascular (CV) disease and mortality risk
marker, is a gut microbiota-derived metabolite as well. Recently, plasma concentrations of …

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

GG Schiattarella, A Sannino, E Toscano… - European heart …, 2017 - academic.oup.com
Aims Gut microbiota-derived metabolite trimethylamine-N-oxide (TMAO) is emerging as a
new potentially important cause of increased cardiovascular risk. The purpose of this meta …

A multi-omic association study of trimethylamine N-oxide

O Manor, N Zubair, MP Conomos, X Xu, JE Rohwer… - Cell reports, 2018 - cell.com
Trimethylamine N-oxide (TMAO) is a circulating metabolite that has been implicated in the
development of atherosclerosis and cardiovascular disease (CVD). In this paper, we identify …

Trimethylamine N-oxide: a harmful, protective or diagnostic marker in lifestyle diseases?

A Nowiński, M Ufnal - Nutrition, 2018 - Elsevier
Diet has been considered a general health determinant for many years. Recent research
shows a connection between gut microbiota composition that is shaped by our diet and …

[HTML][HTML] Trimethylamine N-oxide (TMAO) is not associated with cardiometabolic phenotypes and inflammatory markers in children and adults

S Andraos, B Jones, K Lange, SA Clifford… - Current developments in …, 2021 - Elsevier
ABSTRACT Background Trimethylamine N-oxide (TMAO) is a diet-and microbiome-derived
metabolite and a proposed biomarker of adverse cardiometabolic outcomes. TMAO studies …

Implications of the intestinal microbiota in diagnosing the progression of diabetes and the presence of cardiovascular complications

AM Leustean, M Ciocoiu, A Sava… - Journal of diabetes …, 2018 - Wiley Online Library
The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple
complications with a negative impact on the whole organism. Complications of diabetes may …