[PDF][PDF] The role of mammalian DNA methyltransferases in the regulation of gene expression
J Turek-Plewa, PP Jagodzinski - Cellular and Molecular Biology Letters, 2005 - Citeseer
The term epigenetic modification denotes reversible traits of gene expression that do not
include alterations to the DNA sequence. These epigenetic alterations are responsible for …
include alterations to the DNA sequence. These epigenetic alterations are responsible for …
The DNMT3 family of mammalian de novo DNA methyltransferases
F Chédin - Progress in molecular biology and translational …, 2011 - Elsevier
The deposition of DNA methylation at promoters of transposons, X-linked genes, imprinted
genes, and other lineage-specific genes is clearly associated with long-term transcriptional …
genes, and other lineage-specific genes is clearly associated with long-term transcriptional …
Biochemistry and biology of mammalian DNA methyltransferases
DNA methylation is a stable but not irreversible epigenetic signal that silences gene
expression. It has a variety of important functions in mammals, including control of gene …
expression. It has a variety of important functions in mammals, including control of gene …
Structural basis of DNMT1 and DNMT3A-mediated DNA methylation
DNA methylation, one of the major epigenetic mechanisms, plays critical roles in regulating
gene expression, genomic stability and cell lineage commitment. The establishment and …
gene expression, genomic stability and cell lineage commitment. The establishment and …
Dynamic expression of DNA methyltransferases (DNMTs) in oocytes and early embryos
F Uysal, G Akkoyunlu, S Ozturk - Biochimie, 2015 - Elsevier
Epigenetic mechanisms play critical roles in oogenesis and early embryo development in
mammals. One of these epigenetic mechanisms, DNA methylation is accomplished through …
mammals. One of these epigenetic mechanisms, DNA methylation is accomplished through …
Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions
S Takebayashi, T Tamura, C Matsuoka… - Molecular and cellular …, 2007 - Taylor & Francis
DNA methyltransferase 1 (DNMT1) plays an important role in the inheritance of genomic
DNA methylation, which is coupled to the DNA replication process. Early embryonic lethality …
DNA methylation, which is coupled to the DNA replication process. Early embryonic lethality …
Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases
In mammals, three major DNA methyltransferases, Dnmt1, Dnmt3a, and Dnmt3b, have been
identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns …
identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns …
Stage-by-stage change in DNA methylation status of Dnmt1 locus during mouse early development
Methylation of DNA is involved in tissue-specific gene control, and establishment of DNA
methylation pattern in the genome is thought to be essential for embryonic development …
methylation pattern in the genome is thought to be essential for embryonic development …
Interactions within the mammalian DNA methyltransferase family
JB Margot, AE Ehrenhofer-Murray, H Leonhardt - BMC molecular biology, 2003 - Springer
Background In mammals, epigenetic information is established and maintained via the
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L
MS Kareta, ZM Botello, JJ Ennis, C Chou… - Journal of Biological …, 2006 - ASBMB
The DNMT3-like protein, DNMT3L, is required for germ line DNA methylation, although it is
inactive as a DNA methyltransferase per se. Previous studies have shown that DNMT3L …
inactive as a DNA methyltransferase per se. Previous studies have shown that DNMT3L …