Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
Genomic DNA methylation profiles exhibit substantial variation within the human population,
with important functional implications for gene regulation. So far little is known about the …
with important functional implications for gene regulation. So far little is known about the …
A DNA methylation fingerprint of 1628 human samples
AF Fernandez, Y Assenov, JI Martin-Subero… - Genome …, 2012 - genome.cshlp.org
Most of the studies characterizing DNA methylation patterns have been restricted to
particular genomic loci in a limited number of human samples and pathological conditions …
particular genomic loci in a limited number of human samples and pathological conditions …
[HTML][HTML] Extensive sequence-influenced DNA methylation polymorphism in the human genome
A Hellman, A Chess - Epigenetics & chromatin, 2010 - Springer
Background Epigenetic polymorphisms are a potential source of human diversity, but their
frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an …
frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an …
[HTML][HTML] Population-specificity of human DNA methylation
Background Ethnic differences in human DNA methylation have been shown for a number of
CpG sites, but the genome-wide patterns and extent of these differences are largely …
CpG sites, but the genome-wide patterns and extent of these differences are largely …
Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias, and copy number variation
DNA methylation is an essential epigenetic modification that plays a key role associated with
the regulation of gene expression during differentiation, but in disease states such as …
the regulation of gene expression during differentiation, but in disease states such as …
DNA methylation contributes to natural human variation
DNA methylation patterns are important for establishing cell, tissue, and organism
phenotypes, but little is known about their contribution to natural human variation. To …
phenotypes, but little is known about their contribution to natural human variation. To …
Dynamic DNA methylation across diverse human cell lines and tissues
As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …
a complex relationship with gene expression, plays an important role in defining cell types …
Whole-genome DNA methylation profiling using MethylCap-seq
AB Brinkman, F Simmer, K Ma, A Kaan, J Zhu… - Methods, 2010 - Elsevier
MethylCap-seq is a robust procedure for genome-wide profiling of DNA methylation. The
approach consists of the capture of methylated DNA using the MBD domain of MeCP2, and …
approach consists of the capture of methylated DNA using the MBD domain of MeCP2, and …
[HTML][HTML] The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts
Background DNA methylation plays an essential role in the regulation of gene expression.
While its presence near the transcription start site of a gene has been associated with …
While its presence near the transcription start site of a gene has been associated with …
[HTML][HTML] Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies
Epigenome-wide association studies, which searches for blood-based DNA methylation
signatures associated with environmental exposures and/or disease susceptibilities, is a …
signatures associated with environmental exposures and/or disease susceptibilities, is a …