Polycystin-1 is a novel protein predicted to be a large membrane-spanning glycoprotein with
an extracellular N-terminus and an intracellular C-terminus, harboring several structural …

Mutations in the PKD1 gene are responsible for 85% of cases of autosomal dominant
polycystic kidney disease (ADPKD). This gene encodes a large membrane associated …

Mutations in PKD1 and PKD2, the genes that encode polycystin-1 and polycystin-2
respectively, account for almost all cases of autosomal dominant polycystic kidney disease …

Recently, the gene for the most common form of autosomal dominant polycystic kidney
disease (ADPKD), PKD1 (polycystic kidney disease 1), has been fully characterized and …

Cells from the cysts of patients with autosomal dominant polycystic kidney disease (PKD)
were grown in vitro under standard conditions without the aid of collagen-pretreated …

PKD2 encodes a protein of unknown function that is mutated in 15% of autosomal dominant
polycystic kidney disease (ADPKD) families. We used polyclonal antisera against PKD2 to …

Polycystic kidney disease is the most common heritable disease in humans. In addition to
epithelial cysts in the kidney, liver and pancreas, patients with autosomal dominant …

Autosomal dominant polycystic kidney disease (ADPKD) is a serious, life-threatening
genetic disease in which extensive epithelial-lined cysts develop in the kidneys and, to a …

Polycystin-1, the product of the major gene mutated in autosomal dominant polycystic kidney
disease (ADPKD), has been shown to associate with multiple epithelial cell junctions. Our …

We identified a developmentally regulated gene from mouse kidney whose expression is up-
regulated in metanephrogenic mesenchyme cells when they are induced to differentiate to …