Thyroid hormones play key roles in cellular growth, development and metabolism. Although
there is a strong genetic influence on thyroid hormone levels, the genes involved are widely …

Objective While most of the variation in thyroid function is determined by genetic factors,
single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses …

Thyroid-stimulating hormone (TSH) is a sensitive indicator of thyroid function. High and low
TSH levels reflect hypothyroidism and hyperthyroidism, respectively. Even within the normal …

Thyroid hormones play a critical role in regulation of multiple physiological functions and
thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health …

To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …

Background Hypothyroidism is associated with obesity, and thyroid hormones are involved
in the regulation of body composition, including fat mass. Genome-wide association studies …

Thyroid hormone is essential for normal metabolism and development, and overt
abnormalities in thyroid function lead to common endocrine disorders affecting …

Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To
better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis …

Background: The thyroid plays a key role in development and homeostasis, but it has been
difficult to establish causality with diseases and phenotypic traits because of several …

Objective Minor variation in serum thyroid hormone (TH) levels can have important effects
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …