Cancer cell lines are widely used in many types of cancer research, including studies aimed
at understanding DNA hypermethylation of gene promoters in cancer. Hypermethylation of …

A higher prevalence of epigenetic inactivation of tumor suppressor genes has been reported
in cancer cell line populations compared to primary cancer populations. Cancer-related …

Cancer development and progression is dictated by a series of alterations in genes such as
oncogenes, tumor suppressor genes, DNA repair genes, and others. DNA methylation is an …

CpG island hypermethylation is known to be associated with gene silencing in cancer. This
epigenetic event is generally accepted as a stochastic process in tumor cells resulting from …

The genetic and epigenetic alterations that underlie cancer pathogenesis are rapidly being
identified. This provides novel insights in tumor biology as well as in potential cancer …

Most investigations on the role of DNA methylation in cancer have focused on epigenetic
changes associated with known tumor suppressor genes. This may have led to an …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

Abstract Background Aberrant CpG island promoter DNA hypermethylation is frequently
observed in cancer and is believed to contribute to tumor progression by silencing the …

We have developed a transcriptome-wide approach to identify genes affected by promoter
CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By …

Background Tumor cell lines are commonly used as experimental tools in cancer research,
but their relevance for the in vivo situation is debated. In a series of 11 microsatellite stable …