Characterisation and expression of the PKD-1 protein, polycystin, in renal and extrarenal tissues.
AC Ong, PC Harris, S Biddolph, C Bowker… - Kidney …, 1999 - europepmc.org
Studies of the nature and expression of the PKD-1 gene product, polycystin, have been
complicated by duplication of the PKD-1 gene, the low expression of the PKD-1 gene in …
complicated by duplication of the PKD-1 gene, the low expression of the PKD-1 gene in …
Identification and localization of polycystin, the PKD1 gene product.
L Geng, Y Segal, B Peissel, N Deng… - The Journal of …, 1996 - Am Soc Clin Investig
Polycystin, the product of autosomal dominant polycystic kidney disease (ADPKD) 1 gene
(PKD1) is the cardinal member of a novel class of proteins. As a first step towards …
(PKD1) is the cardinal member of a novel class of proteins. As a first step towards …
Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene
L Foggensteiner, AP Bevan, R Thomas… - Journal of the …, 2000 - journals.lww.com
Mutations in the PKD1 and PKD2 genes account for 85 and 15% of cases of autosomal
dominant polycystic kidney disease, respectively. Polycystin-2, the product of the PKD2 …
dominant polycystic kidney disease, respectively. Polycystin-2, the product of the PKD2 …
Immunological detection of polycystin-1 in human kidney
J Nauta, MA Goedbloed… - Histochemistry and cell …, 2000 - Springer
Polycystin-1 is the protein product of the PKD1 gene. Mutations in this gene are responsible
for most cases of polycystic kidney disease, but little is known about how these mutations …
for most cases of polycystic kidney disease, but little is known about how these mutations …
Expression of polycystin in mouse metanephros and extra-metanephric tissues
MD Griffin, DA O'Sullivan, VE Torres, JP Grande… - Kidney international, 1997 - Elsevier
Expression of polycystin in mouse metanephros and extra-metanephric tissues. The
presence of messenger RNA for the mouse homologue of the polycystic kidney disease 1 …
presence of messenger RNA for the mouse homologue of the polycystic kidney disease 1 …
Polycystin expression is temporally and spatially regulated during renal development
J Van Adelsberg, S Chamberlain… - American Journal of …, 1997 - journals.physiology.org
Mutations in PKD1 cause autosomal dominant polycystic kidney disease (ADPKD), a
common genetic disease in which cysts form from kidney tubules. The predicted product of …
common genetic disease in which cysts form from kidney tubules. The predicted product of …
Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue
A second gene for autosomal dominant polycystic kidney disease (ADPKD), PKD2, has
been recently identified. Using antisera raised to the human PKD2 protein, polycystin-2, we …
been recently identified. Using antisera raised to the human PKD2 protein, polycystin-2, we …
Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development
Autosomal-dominant polycystic kidney disease, one of the most frequent human genetic
disorders, is genetically heterogeneous. Most cases result from mutations of PKD1 or PKD2 …
disorders, is genetically heterogeneous. Most cases result from mutations of PKD1 or PKD2 …
Biochemical characterization of bona fide polycystin-1 in vitro and in vivo
The most common form of autosomal dominant polycystic kidney disease (PKD) results from
mutation of the PKD1 gene on chromosome 16p13. 3. The gene encodes a 14-kb …
mutation of the PKD1 gene on chromosome 16p13. 3. The gene encodes a 14-kb …
Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney.
Polycystic kidney disease 1 (PKD1) is the major locus of the common genetic disorder
autosomal dominant polycystic kidney disease. We have studied PKD1 mRNA, with an …
autosomal dominant polycystic kidney disease. We have studied PKD1 mRNA, with an …