Background Mutations in factor H (HF1) have been reported in a consistent number of
diarrhoea-negative, non-Shiga toxin-associated cases of haemolytic uraemic syndrome …

Mutations in complement factor H (HF1) gene have been reported in non-Shiga toxin-
associated and diarrhoea-negative haemolytic uraemic syndrome (D− HUS). We analysed …

Haemolytic uraemic syndrome (HUS) is a thrombotic microangiopathy (TMA) disorder
characterised by the association of haemolytic anaemia, thrombocytopenia and acute renal …

Background: The aetiology of atypical haemolytic uraemic syndrome (aHUS) is, in contrast
to classical, Shiga-like toxin induced HUS in children, largely unknown. Deficiency of human …

Hemolytic-uremic syndrome (HUS) is a microvasculature disorder leading to
microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Most cases …

Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement
regulation. Disease-associated mutations have been described in the genes encoding the …

Several recent studies have established an association between abnormalities of
complement factor H (FH) and the development of hemolytic uremic syndrome (HUS). To …

Mutations in the plasma complement regulator factor H (CFH) and the transmembrane
complement regulator membrane co-factor protein (MCP) have been shown to predispose to …

BACKGROUND: In a recent study of three families we have found that inherited haemolytic
uraemic syndrome (HUS) maps to a region of chromosome 1q containing the gene for …

Atypical hemolytic uremic syndrome (HUS) presents with the clinical features of
hypertension, microangiopathic hemolytic anemia, and acute renal failure. Both dominant …