About 20% of individuals afflicted with thoracic aortic disease have single-gene mutations
that predispose the vessel to aneurysm formation and/or acute aortic dissection often without …

Background Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic
expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection …

Marfan syndrome is a common inherited disorder of connective tissue caused by deficiency
of the matrix protein fibrillin-1. Effective surgical therapy for the most life-threatening …

Marfan Syndrome (MFS) is a rare connective tissue disorder, resulting from mutations in the
fibrillin-1 gene, characterized by pathologic phenotypes in multiple organs, the most …

Aortic dissection and aneurysm are common clinical problems with life-threatening
consequences; they are also the hallmark of several genetic diseases, including Marfan's …

Aims Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the
Fibrillin-1 gene. It is associated with formation of thoracic aortic aneurysms that can …

Background: Marfan syndrome (MFS), an inherited disorder of connective tissue
characterized by abnormalities in the skeletal, ocular, and cardiovascular systems, is caused …

Background Development of thoracic aortic aneurysms is the most significant clinical
phenotype in patients with Marfan syndrome. An inflammatory response has been described …

Aortic aneurysm is predominantly found in the ascending aorta in patients with Marfan
syndrome (MFS). However, descending aortic disease has emerged as a problem since …

Marfan syndrome (MFS) is a heritable connective tissue disorder caused by pathogenic
variants in the gene coding for the extracellular matrix protein fibrillin-1. While the disease …