Since the discovery of its fundamental involvement in Rett syndrome, methyl CpG binding
protein 2 (MeCP2) has been the focus of an exhaustive biochemical and functional …

Methyl CpG binding protein 2 (MeCP2) was first identified as a nuclear protein with a
transcriptional repressor role that recognizes DNA methylation marks. MeCP2 has a well …

Highlights•MeCP2 modulates cell type-specific, cellular compartment-specific, and
developmental stage-dependent gene expression programs.•Long genes with high levels of …

Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …

Mutations of the methylated DNA binding protein MeCP2, a multifunctional protein that is
thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the …

The methyl-CpG-binding protein 2 (MECP2) serves both organizational and transcriptional
functions in the nucleus, with two well-characterized domains integrally related to these …

Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-
associated multifunctional protein, how MeCP2 integrates external signals and regulates …

Abstract Background Methyl-CpG binding protein 2 (MECP2) is a protein that specifically
binds methylated DNA, thus regulating transcription and chromatin organization. Mutations …

Despite a vast body of literature linking chromatin structure to regulation of gene expression,
the role of architectural proteins in higher order chromatin transitions required for …

DNA methylation, one of the most well-studied epigenetic modifications, is involved in a
wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology …