5-hydroxymethyl-cytosine (5-hmC) is a cytosine modification that is relatively abundant in
mammalian pre-implantation embryos and embryonic stem cells (ESC) derived from …

The conversion of DNA 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) by TET
enzymes represents a significant epigenetic modification, yet its role in early human …

5-Hydroxymethyl-cytosine (5-hmC) is a form of modified cytosine, which has recently
attracted a considerable attention due to its potential role in transcriptional regulation …

Abstract Tet-enzyme-mediated 5-hydroxymethylation of cytosines in DNA plays a crucial role
in mouse embryonic stem cells (ESCs). In RNA also, 5-hydroxymethylcytosine (5hmC) has …

Cytosine hydroxymethylation (5hmC) in mammalian DNA is the product of oxidation of
methylated cytosines (5mC) by Ten-Eleven-Translocation (TET) enzymes. While it has been …

Recent studies have demonstrated that the Ten-eleven translocation (Tet) family proteins
can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) …

DNA methylation at the 5-position of cytosines (5mC) represents an important epigenetic
modification involved in tissue differentiation and is frequently altered in cancer. Recent …

We describe the use of a unique DNA-modification-dependent restriction endonuclease
AbaSI coupled with sequencing (Aba-seq) to map high-resolution hydroxymethylome of …

Abstract Background 5-Hydroxymethylcytosine (5hmC) was recently found to be abundantly
present in certain cell types, including embryonic stem cells. There is growing evidence that …

Recent studies of the demethylation process in murine zygotes have shown that 5‐
methylcytosine (5mC) is first converted into 5‐hydroxymethylcytosine (5hmC) or further …