Genomic DNA methylation: the mark and its mediators
Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …
the mammalian genome and is essential for embryonic viability. With several of the key …
DNA methylation and chromatin–unraveling the tangled web
KD Robertson - Oncogene, 2002 - nature.com
Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved
in regulating transcription and chromatin structure, controlling the spread of parasitic …
in regulating transcription and chromatin structure, controlling the spread of parasitic …
Non-canonical functions of the DNA methylome in gene regulation
JP Reddington, S Pennings, RR Meehan - Biochemical Journal, 2013 - portlandpress.com
Methylation of the cytosine base in DNA, DNA methylation, is an essential epigenetic mark
in mammals that contributes to the regulation of transcription. Several advances have been …
in mammals that contributes to the regulation of transcription. Several advances have been …
DNA methylation‐mediated epigenetic control
A Rottach, H Leonhardt, F Spada - Journal of cellular …, 2009 - Wiley Online Library
During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …
changes without any change in the DNA sequence. The underlying changes of gene …
DNA methylation and DNA methyltransferases
JR Edwards, O Yarychkivska, M Boulard… - Epigenetics & …, 2017 - Springer
The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …
have their origin many years in the past, at a time when the structure of the mammalian …
Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …
DNA methylation: past, present and future directions
KD Robertson, P A. Jones - Carcinogenesis, 2000 - academic.oup.com
DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …
DNA methylation and gene expression
Z Siegfried, I Simon - Wiley Interdisciplinary Reviews: Systems …, 2010 - Wiley Online Library
Methylation of cytosines is the key epigenetic modification of DNA in eukaryotes and is
associated with a repressed chromatin state and inhibition of gene expression. The …
associated with a repressed chromatin state and inhibition of gene expression. The …
DNA methylation and methyl-CpG binding proteins: developmental requirements and function
O Bogdanović, GJC Veenstra - Chromosoma, 2009 - Springer
DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …
The diverse roles of DNA methylation in mammalian development and disease
MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …
methylation has numerous functions: it is implicated in the repression of transposons and …
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