DNA methylation in early development
TM Geiman, K Muegge - Molecular Reproduction and …, 2010 - Wiley Online Library
Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …
proceeding to a fully functioning adult animal occurs through an intricate program of …
The role of DNA methylation in mammalian development
CE Senner - Reproductive biomedicine online, 2011 - Elsevier
DNA methylation is involved in a number of important processes such as maintaining
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …
Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development
M Monk, M Boubelik, S Lehnert - Development, 1987 - journals.biologists.com
This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …
occurring during embryonic development. The egg genome is strikingly undermethylated …
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos
DM Messerschmidt, BB Knowles… - Genes & …, 2014 - genesdev.cshlp.org
Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …
embryonic development, cells are directed toward their future lineages, and DNA …
DNA methylation and demethylation: a pathway to gametogenesis and development
W Dean - Molecular Reproduction and Development, 2014 - Wiley Online Library
The generation of gametes falls between two reprogramming phases. These phases are
characterised by profound periods of transcriptional activity, which define and reinforce …
characterised by profound periods of transcriptional activity, which define and reinforce …
Methylation dynamics in the early mammalian embryo: implications of genome reprogramming defects for development
T Haaf - DNA methylation: development, genetic disease and …, 2006 - Springer
In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …
parent-specific epigenetic reprogramming during preimplantation development. The …
DNA methylation reprogramming during mammalian development
Y Zeng, T Chen - Genes, 2019 - mdpi.com
DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …
mammalian genome that plays critical roles in chromatin structure and gene expression. In …
DNA methylation and the preservation of cell identity
O Bogdanović, R Lister - Current opinion in genetics & development, 2017 - Elsevier
DNA methylation is a major epigenetic modification of vertebrate genomes that is mostly
associated with transcriptional repression. During embryogenesis, DNA methylation …
associated with transcriptional repression. During embryogenesis, DNA methylation …
Dynamic regulation of DNA methylation during mammalian development
S Guibert, T Forné, M Weber - Epigenomics, 2009 - Taylor & Francis
DNA methylation occurs on cytosines, is catalyzed by DNA methyltransferases (DNMTs),
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …
De novo DNA methylation: a germ cell perspective
SA Smallwood, G Kelsey - Trends in Genetics, 2012 - cell.com
DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …
genome that has widespread influences on gene expression. During germ-cell specification …
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