Over three decades ago DNA methylation had been suggested to play a role in the
regulation of gene expression. This chapter reviews the development of this field of research …

Gene expression in cells is determined by the epigenetic state of chromatin. Therefore, the
study of epigenetic changes is very important to understand the regulatory mechanism of …

The faithful transmission of DNA methylation patterns through cell divisions is essential for
the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment …

DNA methylation has the ability to repress transcription; in addition, the pattern of
methylation can be stably inherited during successive cell divisions [1]. These two features …

Background DNA methylation in mammals is an epigenetic mark necessary for normal
embryogenesis. During development active loss of methylation occurs in the male …

DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …

In mammals, the embryonic genome is transcriptionally inactive after fertilization and
embryonic gene expression is initiated during the preimplantation developmental period …

Active demethylation of cytosine residues in the sperm genome before forming a functional
zygotic nucleus is thought to be an important function of the oocyte cytoplasm for …

The epigenome consists of chemical changes in DNA and chromatin that without modifying
the DNA sequence modulate gene expression and cellular phenotype. The epigenome is …

ABSTRACT DNA methylation reprogramming (DMR) during preimplantation development
erases differentiation-associated, unessential epigenetic information accumulated during …