DNA methylation is an epigenetic modification that plays an important role in gene
regulation. It can be influenced by stochastic events, environmental factors and …

Abnormal patterns of DNA methylation are observed in many diseases such as tumors and
imprinting disorders. Little is known about inter-individual and gender specific variations …

Background DNA methylation is a contributing factor to both rare and common human
diseases, and plays a major role in development and gene silencing. While the variation of …

Background Epigenetic polymorphisms are a potential source of human diversity, but their
frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an …

DNA methylation is a heritable modification of genomic DNA central to development,
imprinting, transcriptional regulation, chromatin structure, and overall genomic stability …

Background DNA methylation plays an essential role in the regulation of gene expression.
While its presence near the transcription start site of a gene has been associated with …

The methylation of cytosines in CpG dinucleotides is essential for cellular differentiation and
the progression of many cancers, and it plays an important role in gametic imprinting. To …

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …

DNA methylation is known to be associated with cell differentiation, aging, disease and
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …

Background DNA methylation is a major epigenetic modification important for regulating
gene expression and suppressing spurious transcription. Most methods to scan the genome …