DNA methylation is a vital component of the epigenetic machinery that orchestrates changes
in multiple genes and helps regulate gene expression in all known vertebrates. We …

The role of DNA cytosine methylation, an epigenetic regulator of chromatin structure and
function, during normal and pathological brain development and aging remains unclear …

Epigenetic dysregulation of gene expression is thought to be critically involved in the
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …

Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …

Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …

Learning and memory are two of the fundamental cognitive functions that confer us the
ability to accumulate knowledge from our experiences. Although we use these two mental …

Gene expression is modulated by epigenetic factors that come in varying forms, such as
DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …

Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Evidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset
Alzheimer's disease (LOAD), but little has been done on a genome-wide scale to identify …