Rethinking how DNA methylation patterns are maintained
DNA methylation patterns are set up early in mammalian development and are then copied
during the division of somatic cells. A long-established model for the maintenance of these …
during the division of somatic cells. A long-established model for the maintenance of these …
New concepts in DNA methylation
A Jeltsch, RZ Jurkowska - Trends in biochemical sciences, 2014 - cell.com
The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …
Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions
S Takebayashi, T Tamura, C Matsuoka… - Molecular and cellular …, 2007 - Taylor & Francis
DNA methyltransferase 1 (DNMT1) plays an important role in the inheritance of genomic
DNA methylation, which is coupled to the DNA replication process. Early embryonic lethality …
DNA methylation, which is coupled to the DNA replication process. Early embryonic lethality …
[HTML][HTML] Interactions within the mammalian DNA methyltransferase family
JB Margot, AE Ehrenhofer-Murray, H Leonhardt - BMC molecular biology, 2003 - Springer
Background In mammals, epigenetic information is established and maintained via the
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
We used mouse embryonic stem (ES) cells with systematic gene knockouts for DNA
methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a …
methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a …
Dnmt2-dependent methylomes lack defined DNA methylation patterns
G Raddatz, PM Guzzardo, N Olova… - Proceedings of the …, 2013 - National Acad Sciences
Several organisms have retained methyltransferase 2 (Dnmt2) as their only candidate DNA
methyltransferase gene. However, information about Dnmt2-dependent methylation patterns …
methyltransferase gene. However, information about Dnmt2-dependent methylation patterns …
[HTML][HTML] Demethylase activity is directed by histone acetylation
N Cervoni, M Szyf - Journal of Biological Chemistry, 2001 - ASBMB
Mammalian genomes are compartmentalized into dense inactive chromatin that is
hypermethylated and active open chromatin that is hypomethylated. It is generally accepted …
hypermethylated and active open chromatin that is hypomethylated. It is generally accepted …
Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA
Proper DNA methylation patterns are essential for mammalian development and
differentiation. DNA methyltransferases (DNMTs) primarily establish and maintain global …
differentiation. DNA methyltransferases (DNMTs) primarily establish and maintain global …
Regulation of DNA methyltransferase 1 by interactions and modifications
W Qin, H Leonhardt, G Pichler - Nucleus, 2011 - Taylor & Francis
DNA methylation plays a central role in the epigenetic regulation of gene expression during
development and disease. Remarkably, the complex and changing patterns of genomic …
development and disease. Remarkably, the complex and changing patterns of genomic …
[HTML][HTML] Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern
J Espada, E Ballestar, MF Fraga, A Villar-Garea… - Journal of Biological …, 2004 - ASBMB
DNA methyltransferase 1 (DNMT1) plays an essential role in murine development and is
thought to be the enzyme primarily responsible for maintenance of the global methylation …
thought to be the enzyme primarily responsible for maintenance of the global methylation …