We investigated the role of granulocyte macrophage colony-stimulating factor (GM-CSF) in
host defense in a murine model of pulmonary cryptococcosis induced by intratracheal …

Patients with acquired deficiency in GM-CSF are susceptible to infections with Cryptococcus
neoformans and other opportunistic fungi. We previously showed that GM-CSF protects …

Allergic bronchopulmonary mycosis (ABPM) is a hypersensitivity lung disease in which
fungal colonization is accompanied by an allergic response to the fungus. Using a mouse …

The importance of T cell-mediated immunity for resistance to the disease (cryptococcal
disease) caused by Cryptococcus neoformans is incontrovertible, but whether Ab immunity …

The pathogenesis of Cryptococcus neoformans pulmonary infection in the rat was studied
after intratracheal inoculation. Lungs were examined at various times following infection for …

Clearance of pulmonary infection with the fungal pathogen Cryptococcus neoformans is
associated with the accumulation and activation of lung macrophages. However, the …

Alternative macrophage activation is associated with exacerbated disease in murine models
of pulmonary cryptococcosis. The present study evaluated the efficacy of interferon-γ …

Background Cryptococcus neoformans (C. neoformans) is a globally distributed fungal
pathogen with the potential to cause serious disease, particularly among immune …

The pathogenesis of pulmonary Cryptococcus neoformans infection and the efficacy of
passive immunoglobulin G1 (IgG1) administration were investigated in B-cell-deficient and …

Although Cryptococcus neoformans is recognized for its ability to cause
meningoencephalitis and pneumonia among immunocompromised persons, subclinical …