A widespread and highly conserved family of apparently inactivated derivatives of archaeal
B-family DNA polymerases is described. Phylogenetic analysis shows that the inactivated …

All archaeal DNA-dependent DNA polymerases sequenced to date are homologous to
family B DNA polymerases from eukaryotes and eubacteria. Presently, representatives of the …

Eukaryotes and archaea both possess multiple genes coding for family B DNA polymerases.
In animals and fungi, three family B DNA polymerases, alpha, delta, and epsilon, are …

The elaborate eukaryotic DNA replication machinery evolved from the archaeal ancestors
that themselves show considerable complexity. Here we discuss the comparative genomic …

In this study we report on the evidence that an alpha-like DNA polymerase purified from the
thermoacidophilic archaeon Sulfolobus solfataricus has a modular organization of its …

Abstract B-family DNA-directed DNA polymerases are DNA replication enzymes found in
Eukaryota, Archaea, large DNA viruses, and in some, but not all, bacteria. Several …

Archaea-specific D-family DNA polymerase forms a heterotetramer consisting of two large
polymerase subunits and two small exonuclease subunits. We analyzed the structure of the …

Three family B DNA polymerase genes, designated B1, B2, and B3, were cloned from the
thermoacidophilic crenarchaeon Sulfurisphaera ohwakuensis, and sequenced. Deduced …

In order to extend the limited knowledge about crenarchaeal DNA polymerases, we cloned a
gene encoding a family B DNA polymerase from the hyperthermophilic crenarchaeon …

Most known archaeal DNA polymerases belong to the type B family, which also includes the
DNA replication polymerases of eukaryotes, but maintain high fidelity at extreme conditions …