Eukaryotic DNA methylation
DN Cooper - Human genetics, 1983 - Springer
Summary Eukaryotic genomes contain 5-methylcytosine (5mC) as a rare base. 5mC arises
by postsynthetic modification of cytosine and occurs, at least in animals, predominantly in …
by postsynthetic modification of cytosine and occurs, at least in animals, predominantly in …
Functions for DNA methylation in vertebrates
AP Bird - Cold Spring Harbor Symposia on Quantitative …, 1993 - symposium.cshlp.org
The distribution of 5-methylcytosine (m5C) in vertebrate genomes is strikingly different from
that in all other animal genomes that have been examined. In the vertebrates, almost all …
that in all other animal genomes that have been examined. In the vertebrates, almost all …
DNA methylation patterns: an additional level of information?
M Szyf - Biochemistry and cell biology, 1991 - cdnsciencepub.com
The DNA of many organisms contains modified bases such as 5-methylcytosine and 6-
methyladenine, in addition to the four unmodified bases (reviewed by Razin and Szyf …
methyladenine, in addition to the four unmodified bases (reviewed by Razin and Szyf …
Gene methylation patterns and expression
A Yeivin, A Razin - DNA methylation: molecular biology and biological …, 1993 - Springer
Several lines of evidence strongly indicate that methylation of cytosine residues within CpG
dinucleotides are implicated in the regulation of gene expression in eukaryotes. Transfection …
dinucleotides are implicated in the regulation of gene expression in eukaryotes. Transfection …
DNA methylation in early mammalian development
D Jähner, R Jaenisch - DNA methylation: Biochemistry and biological …, 1984 - Springer
The genomic DNAs of vertebrates and many invertebrates contain 5-methylcytosine (5-
meCyt) as the only modified base (Table 10.1). Considerable interest in DNA methylation …
meCyt) as the only modified base (Table 10.1). Considerable interest in DNA methylation …
DNA methylation and gene expression
H Cedar - DNA methylation: biochemistry and biological …, 1984 - Springer
Understanding the mechanisms involved in the regulation of gene expression in eukaryotic
organisms is one of the major challenges facing the modern molecular biologist. Despite …
organisms is one of the major challenges facing the modern molecular biologist. Despite …
Structure, function and regulation of mammalian DNA methyltransferase
H Leonhardt, TH Bestor - DNA methylation: molecular biology and …, 1993 - Springer
The haploid mammalian genome contains~ 5× 10 7 CpG dinucleotides (Schwartz et al.,
1962), about 60% of which are methylated at the 5 position of the cytosine residue (Bestor et …
1962), about 60% of which are methylated at the 5 position of the cytosine residue (Bestor et …
DNA methylation and DNA methyltransferases
JR Edwards, O Yarychkivska, M Boulard… - Epigenetics & …, 2017 - Springer
The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …
have their origin many years in the past, at a time when the structure of the mammalian …
Gene methylation patterns and expression
J Yisraeli, M Szyf - DNA methylation: biochemistry and biological …, 1984 - Springer
Three basic approaches have been employed in the study of the effect of DNA methylation
of particular genes on their expression. One approach uses chemicals that cause …
of particular genes on their expression. One approach uses chemicals that cause …
DNA methylation is a reversible biological signal
S Ramchandani, SK Bhattacharya… - Proceedings of the …, 1999 - National Acad Sciences
The pattern of DNA methylation plays an important role in regulating different genome
functions. To test the hypothesis that DNA methylation is a reversible biochemical process …
functions. To test the hypothesis that DNA methylation is a reversible biochemical process …