C3 glomerulopathy (C3G) is a newly defined clinical entity comprising glomerular lesions
with predominant C3 staining. Under this definition are now included membranoproliferative …

Rationale & Objective C3 glomerulopathy (C3G), a form of glomerulonephritis associated
with dysregulation of the alternative complement pathway, occurs either as dense deposit …

ABSTRACT Background C3 glomerulonephritis (C3GN) is caused by alternate complement
pathway over-activation. It frequently progresses to end-stage renal disease, recurs in two …

Background Dense deposit disease (DDD), a C3 glomerulopathy (C3G), is a rare disease
with unfavorable progression towards end-stage kidney disease. The pathogenesis of DDD …

Abstract Background C3 glomerulopathies (C3G) are characterized by uncontrolled
activation of the alternative pathway of complement. In most patients these diseases …

Various complement-mediated renal disorders are treated currently with the complement
inhibitor eculizumab. By blocking the cleavage of C5, this monoclonal antibody prevents cell …

Abstract C3 glomerulopathy (C3G) is a clinicopathologic entity secondary to dysregulation of
the alternative complement pathway in plasma and the glomerular microenvironment. The …

Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative
complement pathway dysregulation, is associated with a high rate of recurrence and graft …

Abstract Background Complement 3 glomerulopathy (C3GN) is a newly proposed
subcategory of glomerular disease with features including membranoproliferative …

Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising of
dense deposit disease and C3 glomerulonephritis. The key histological feature is the …