Introduction: The use of assisted reproductive technologies (ART), namely in-vitro
fertilization (IVF) and intracytoplasmic sperm injection (ICSI), has recently caused concerns …

DNA methylation at H19 ICR1 was investigated in the placenta from pregnancies conceived
by in vitro fertilization, intracytoplasmic sperm injection, and from natural conception. Our …

OBJECTIVE: To determine whether hypomethylation of the IGF2/H19 differnetially
methylated region (DMR) in the placenta is associated with pregnancies conceived by in …

The growth and maturation of the oocyte is a complex and highly regulated process. An
important aspect of oocyte maturation is the establishment of the correct epigenetic …

Recent studies suggest that IVF and assisted reproduction technologies (ART) may result in
abnormal genomic imprinting, leading to an increased frequency of Angelman syndrome …

Although more and more children are born by Assisted Reproductive Technologies (ART),
ART safety has not fully been demonstrated. Notably, ART could disturb the delicate step of …

Recent studies have identified an increased incidence of the normally rare imprinting
disorders, Beckwith-Wiedemann syndrome (BWS; NIM130650) and Angelman syndrome …

Objective Dynamic epigenetic changes occur during early human development.
Environmental manipulations, such as hormone-induced super-ovulation, in vitro …

Allele-specific DNA methylation is an important tool in studies of genomic imprinting. The
IGF2/H19 imprinting control region (ICR1) is essential for normal fetal and placental growth …

Voor de meeste genen wordt zowel het paternaal overgeërfde DNA als het maternaal
overgeërfde DNA tot expressie gebracht (twee actieve kopijen). Bij genen met imprinting …