No single method of DNA methylation analysis will be appropriate for every application. By
understanding the type of information provided by, and the inherent potential for bias and …

DNA methylation is a major epigenetic modification that controls gene expression in
physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are …

Animal studies have provided direct evidence that dietary factors induce changes in DNA
methylation patterns. In humans, studies on diet and DNA methylation have yielded …

Methylation has been implied in a number of biological processes and has been shown to
vary under environmental influences as well as in age. Most results on the correlation of …

The relationship between levels of DNA methylation and gene activity has been known for
some time. Many of the early procedures developed gave only somewhat limited information …

Background: Animal models show that periconceptional supplementation with folic acid,
vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated …

DNA methylation is a key component of the epigenetic machinery that is responsible for
regulating gene expression and, therefore, cell function. Patterns of DNA methylation …

DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …

We describe a highly reproducible and multiplexed method, the GoldenGate assay for
methylation, for high-throughput quantitative measurements of DNA methylation. It can …

DNA methylation is the most extensively studied mechanism of epigenetic gene regulation.
Increasing evidence indicates that DNA methylation is labile in response to nutritional and …