Acute symptomatic neonatal seizures in preterm newborns are a relevant clinical challenge
due to the presence of many knowledge gaps. Etiology-wise, acute symptomatic seizures …

Neonatal seizures are the most common neurological event in newborns, showing higher
prevalence in preterm than in full-term infants. In the majority of cases they represent acute …

Acute symptomatic seizures caused by either diffuse or focal perinatal hypoxic–ischemic
insults and intracranial hemorrhage in term newborns make up the large majority of all …

Pharmacologic treatment options for neonatal seizures have expanded over the past 2
decades, and there is no consensus on optimal treatment strategy. We systematically …

Therapeutic options currently available for neonatal seizures are still unsatisfactory both in
terms of efficacy and of risk for long-term neurotoxicity, even if there is growing recognition of …

Seizures occur more often during the neonatal period than at any other period of life. Precise
incidence is difficult to delineate and depends on study population and criteria used for …

The risk of seizure is increased in premature neonates compared to full term infants, with a
distinct profile of etiologies, timing and character. Despite improvements in neonatal care …

Aim The existing treatment options for neonatal seizures have expanded over the last few
decades, but no consensus has been reached regarding the optimal therapeutic protocols …

The treatment of neonatal seizures has not changed significantly over the last 50 years
despite advances in antiepileptic drug (AED) development for older children and adults …

Medically refractory neonatal seizures represent a major therapeutic challenge in neonatal
intensive care units. Conventional antiepileptic drugs demonstrate limited efficacy. Previous …