Human plasma-like medium (HPLM) induces Cryptococcus neoformans in vivo cell morphologies

E G. Mozo, O Ross, R Yuecel, IM Dambuza… - Msphere, 2024 - Am Soc Microbiol
The fungal pathogen Cryptococcus neoformans (C. neoformans) forms yeast cells of
different sizes and morphological characteristics during infection. These features are usually …

The outcome of Cryptococcus neoformansintracellular pathogenesis in human monocytes

M Alvarez, T Burn, Y Luo, L Pirofski, A Casadevall - BMC microbiology, 2009 - Springer
Background Cryptococcus neoformans is an encapsulated yeast that is a facultative
intracellular pathogen. The interaction between macrophages and C. neoformans is critical …

The Buoyancy of Cryptococcus neoformans Is Affected by Capsule Size

R Vij, RJB Cordero, A Casadevall - Msphere, 2018 - Am Soc Microbiol
Cryptococcus neoformans is an environmental pathogenic fungus with a worldwide
geographical distribution that is responsible for hundreds of thousands of human …

Cell wall composition in Cryptococcus neoformans is media dependent and alters host response, inducing protective immunity

R Upadhya, WC Lam, CR Hole, JG Vasselli… - Frontiers in fungal …, 2023 - frontiersin.org
Introduction Cryptococcus neoformans is a basidiomycete fungus that can cause
meningoencephalitis, especially in immunocompromised patients. Cryptococcus grows in …

Two Methods of Measuring Cryptococcus neoformans Fungal Burden in Macrophages

E Smith-Peavler, LM Sircy, DE Nelson… - … : Methods and Protocols, 2024 - Springer
The ability of C. neoformans to survive and replicate within host phagocytes enables it to
evade the immune system and allows for persistence of the infection. As such, measuring …

Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide …

SC Tucker, A Casadevall - Proceedings of the National …, 2002 - National Acad Sciences
Cryptococcus neoformans (CN), an encapsulated, ubiquitous environmental yeast, is
pathogenic for humans, primarily those with compromised immune function. CN is believed …

Lineages derived from Cryptococcus neoformans type strain H99 support a link between the capacity to be pleomorphic and virulence

KE Fernandes, JA Fraser, DA Carter - MBio, 2022 - Am Soc Microbiol
The pathogenic yeast Cryptococcus neoformans causes nearly 200,000 deaths annually in
immunocompromised individuals. Cryptococcus cells can undergo substantial …

Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo

AJ Guimarães, S Frases, RJB Cordero… - Cellular …, 2010 - Wiley Online Library
The polysaccharide capsule of the fungus Cryptococcus neoformans is its main virulence
factor. In this study, we determined the effects of mannitol and glucose on the capsule and …

The Intracellular Life of Cryptococcus neoformans

C Coelho, AL Bocca… - Annual Review of …, 2014 - annualreviews.org
Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological
studies of human populations show a high prevalence of human infection, which rarely …

Cryptococcus neoformans Is a Facultative Intracellular Pathogen in Murine Pulmonary Infection

M Feldmesser, Y Kress, P Novikoff… - Infection and …, 2000 - Am Soc Microbiol
To produce chronic infection, microbial pathogens must escape host immune defenses.
Infection with the human pathogenic fungus Cryptococcus neoformans is typically chronic …