We have examined the methylation status of the zebrafish genome during early
embryogenesis and we find evidence that methylation fluxes do occur in that organism. The …

DNA methylation constitutes an important epigenetic factor in the control of genetic
information. In this study, we analyzed expression of the DNA methyltransferase gene and …

methylcytosine is a major epigenetic modification that is sometimes called" the fifth
nucleotide." However, our knowledge of how offspring inherit the DNA methylome from …

The levels of genomic DNA methylation in vertebrate species display a wide range of
developmental dynamics. Here, we show that in contrast to mice, the paternal genome of the …

This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …

Fig. 1 High levels of DNA methylation in gametes and early embryonic stages of zebrafish. a,
A Southern blot of DNA samples (100 ng) from sperm, adult tail and embryonic stages (2.2 h …

The DNA methylome is re-patterned during discrete phases of vertebrate development. In
zebrafish, there are 2 waves of global DNA demethylation and re-methylation: the first …

DNA methylation on cytosine in vertebrates such as zebrafish serves to silence gene
expression by interfering with the binding of certain transcription factors and through the …

Background Zygotic genome activation (ZGA) occurs at the mid-blastula transition (MBT) in
zebrafish and is a period of extensive chromatin remodeling. Genome-scale gametic …

DNA methylation reprogramming, the erasure of DNA methylation patterns shortly after
fertilization and their reestablishment during subsequent early development, is essential for …