Embryo development proceeds from a cascade of gene activation and repression events
controlled by epigenetic modifications of DNA and histones. Little is known about epigenetic …

DNA methylation is a major epigenetic modification that undergoes dramatic changes in two
epigenetic reprogramming windows during development: first in preimplantation embryos …

Background Enhancers, not promoters, are the most dynamic in their DNA methylation
status throughout development and differentiation. Generally speaking, enhancers that are …

Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …

Mouse embryos undergo genome-wide methylation reprogramming by demethylation in
early preimplantation development, followed by remethylation thereafter. Here we show that …

Methylation of cytosines in the CG context (mCG) is the most abundant DNA modification in
vertebrates that plays crucial roles in cellular differentiation and identity. After fertilization …

DNA methylation plays important roles during development. However, the DNA methylation
reprogramming of functional elements has not been fully investigated during mammalian …

In mammals, active demethylation of cytosine methylation in the sperm genome prior to
forming a functional zygotic nucleus is thought to be a function of the oocyte cytoplasm …

An obstacle to progress in understanding eukaryotic DNA methylation has been the lack of a
good genetic systemthe most favorable eukaryotes for genetic analysis (yeasts …

During embryonic development in mammals, most of the methylated cytosines in the
paternal genome are converted to 5-hydroxymethyldeoxycytidine (hmC), as part of DNA …