DNA methylation in the germline is among the most important factors influencing the
evolution of mammalian genomes. Yet little is known about its evolutionary rate or the …

Although it is well known that DNA methylation serves to repress gene expression, precisely
how it functions during the process of development remains unclear. Here, we propose that …

Some of the key players of the methylation machinery are now in hand, offering an
opportunity to resolve contentious issues in the field of methylation. Perhaps the most …

We have examined the relative methylation levels of several dispersed repeated and low-
copy-number gene sequences during gametogenesis and early embryogenesis. Southern …

The germline is the only cellular lineage capable of transferring genetic information from one
generation to the next. Intergenerational transmission of epigenetic memory through the …

DNA methylation is a major epigenetic modification of vertebrate genomes that is mostly
associated with transcriptional repression. During embryogenesis, DNA methylation …

DNA methylation is a key epigenetic modification in the vertebrate genomes known to be
involved in biological processes such as regulation of gene expression, DNA structure and …

DNA methylation is a fundamental epigenetic modification in vertebrate genomes and a
small fraction of genomic regions is hypomethylated. Previous studies have implicated …

DNA methylation is involved in a number of important processes such as maintaining
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …

Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …