Evolutionary expansion of DNA hypomethylation in the mammalian germline genome
DNA methylation in the germline is among the most important factors influencing the
evolution of mammalian genomes. Yet little is known about its evolutionary rate or the …
evolution of mammalian genomes. Yet little is known about its evolutionary rate or the …
The role of DNA methylation in genome-wide gene regulation during development
Although it is well known that DNA methylation serves to repress gene expression, precisely
how it functions during the process of development remains unclear. Here, we propose that …
how it functions during the process of development remains unclear. Here, we propose that …
At the end of the millennium, a view of the end
JW Shay - nature genetics, 1999 - nature.com
Some of the key players of the methylation machinery are now in hand, offering an
opportunity to resolve contentious issues in the field of methylation. Perhaps the most …
opportunity to resolve contentious issues in the field of methylation. Perhaps the most …
Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse.
JP Sanford, HJ Clark, VM Chapman… - Genes & …, 1987 - genesdev.cshlp.org
We have examined the relative methylation levels of several dispersed repeated and low-
copy-number gene sequences during gametogenesis and early embryogenesis. Southern …
copy-number gene sequences during gametogenesis and early embryogenesis. Southern …
Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
The germline is the only cellular lineage capable of transferring genetic information from one
generation to the next. Intergenerational transmission of epigenetic memory through the …
generation to the next. Intergenerational transmission of epigenetic memory through the …
DNA methylation and the preservation of cell identity
O Bogdanović, R Lister - Current opinion in genetics & development, 2017 - Elsevier
DNA methylation is a major epigenetic modification of vertebrate genomes that is mostly
associated with transcriptional repression. During embryogenesis, DNA methylation …
associated with transcriptional repression. During embryogenesis, DNA methylation …
DNA methylation, epigenetics, and evolution in vertebrates: facts and challenges
A Varriale - International journal of evolutionary biology, 2014 - Wiley Online Library
DNA methylation is a key epigenetic modification in the vertebrate genomes known to be
involved in biological processes such as regulation of gene expression, DNA structure and …
involved in biological processes such as regulation of gene expression, DNA structure and …
Large hypomethylated domains serve as strong repressive machinery for key developmental genes in vertebrates
R Nakamura, T Tsukahara, W Qu, K Ichikawa… - …, 2014 - journals.biologists.com
DNA methylation is a fundamental epigenetic modification in vertebrate genomes and a
small fraction of genomic regions is hypomethylated. Previous studies have implicated …
small fraction of genomic regions is hypomethylated. Previous studies have implicated …
The role of DNA methylation in mammalian development
CE Senner - Reproductive biomedicine online, 2011 - Elsevier
DNA methylation is involved in a number of important processes such as maintaining
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …
Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos
W Shi, F Dirim, E Wolf, V Zakhartchenko… - Biology of …, 2004 - academic.oup.com
Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …