Timing of eculizumab therapy for C3 glomerulonephritis
L Rodriguez-Osorio, A Ortiz - Clinical kidney journal, 2015 - academic.oup.com
Eculizumab is an anti-C5 antibody that inhibits C5 cleavage and prevents the generation of
the terminal complement complex C5b-9. Eculizumab is licensed to treat paroxysmal …
the terminal complement complex C5b-9. Eculizumab is licensed to treat paroxysmal …
Treating C3 glomerulopathy with eculizumab
T Welte, F Arnold, J Kappes, M Seidl, K Häffner… - BMC nephrology, 2018 - Springer
Abstract Background C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with
grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well …
grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well …
Eculizumab-induced reversal of dialysis-dependent kidney failure from C3 glomerulonephritis
M Inman, G Prater, H Fatima… - Clinical Kidney …, 2015 - academic.oup.com
Abstract C3 glomerulopathy (C3G) is characterized by C3 deposits with minimal
immunoglobulin deposition caused by alternative complement pathway dysregulation …
immunoglobulin deposition caused by alternative complement pathway dysregulation …
Eculizumab and recurrent C3 glomerulonephritis
S Gurkan, B Fyfe, L Weiss, X Xiao, Y Zhang… - Pediatric Nephrology, 2013 - Springer
Background Hyperactivity of the alternative complement pathway is the principle defect in
C3 glomerulopathies (C3G). Eculizumab, a monoclonal antibody that binds C5 to prevent …
C3 glomerulopathies (C3G). Eculizumab, a monoclonal antibody that binds C5 to prevent …
Eculizumab for treatment of rapidly progressive C3 glomerulopathy
M Le Quintrec, A Lionet, C Kandel, F Bourdon… - American Journal of …, 2015 - Elsevier
C3 glomerulopathy (C3G) is a prototypic complement-mediated kidney disease. Rapidly
progressive forms of C3G usually respond poorly to conventional treatments. We report on …
progressive forms of C3G usually respond poorly to conventional treatments. We report on …
Eculizumab in post-transplant C3 glomerulonephritis caused by a C3 mutation
JS Kim, KW Foster, SG Westphal - Clinical nephrology, 2020 - search.proquest.com
C3 glomerulonephritis (C3GN) is a disorder of excess alternative complement activation
leading to glomerular injury. Following kidney transplantation, C3GN has a high recurrence …
leading to glomerular injury. Following kidney transplantation, C3GN has a high recurrence …
Pathology after eculizumab in dense deposit disease and C3 GN
LC Herlitz, AS Bomback, GS Markowitz… - Journal of the …, 2012 - journals.lww.com
Eculizumab might benefit C3 glomerulopathies mediated by dysregulation of the alternative
complement pathway. Here, we report renal biopsy findings before and after eculizumab …
complement pathway. Here, we report renal biopsy findings before and after eculizumab …
Utilizing therapeutic drug monitoring to optimize therapy with eculizumab and mycophenolate mofetil in a child with C3 glomerulonephritis
M Riedl Khursigara, E Chung, J Tjon, D Noone… - Pediatric …, 2023 - Springer
Abstract Background C3 glomerulonephritis (C3GN) can be a devastating disease with poor
response to immunosuppressive therapy. Complement inhibition with eculizumab has had …
response to immunosuppressive therapy. Complement inhibition with eculizumab has had …
Eculizumab as a treatment for C3 glomerulopathy: a single-center retrospective study
T Welte, F Arnold, L Westermann, FA Rottmann… - BMC nephrology, 2023 - Springer
Abstract Background C3 Glomerulopathy (C3G) is a rare glomerular disease caused by
dysregulation of the complement pathway. Based on its pathophysiology, treatment with the …
dysregulation of the complement pathway. Based on its pathophysiology, treatment with the …
Patterns of clinical response to eculizumab in patients with C3 glomerulopathy
M Le Quintrec, AL Lapeyraque, A Lionet… - American Journal of …, 2018 - Elsevier
Background Cases reports and small series of patients with C3 glomerulopathy have
reported variable efficacy of eculizumab. Study Design Case series of C3 glomerulopathy …
reported variable efficacy of eculizumab. Study Design Case series of C3 glomerulopathy …