DNA methylation in the pathology of Alzheimer's disease: from gene to cognition

CH Poon, LSR Tse, LW Lim - Annals of the New York Academy …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is a debilitating disorder that manifests with amyloid beta plaque
deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although …

Epigenetics in Alzheimer's disease: perspective of DNA methylation

TJ Qazi, Z Quan, A Mir, H Qing - Molecular Neurobiology, 2018 - Springer
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

JAY Roubroeks, RG Smith… - Journal of …, 2017 - Wiley Online Library
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …

Amyloid-β alters the DNA methylation status of cell-fate genes in an Alzheimer's disease model

N Taher, C McKenzie, R Garrett… - Journal of …, 2014 - content.iospress.com
Alzheimer's disease (AD) is characterized by neurofibrillary tangles and extracellular
amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding …

Opening up the DNA methylome of dementia

R Delgado-Morales, M Esteller - Molecular psychiatry, 2017 - nature.com
Dementia is a complex clinical condition characterized by several cognitive impairments that
interfere with patient independence in executing everyday tasks. Various neurodegenerative …

DNA methylation impacts on learning and memory in aging

L Liu, T van Groen, I Kadish, TO Tollefsbol - Neurobiology of aging, 2009 - Elsevier
Learning and memory are two of the fundamental cognitive functions that confer us the
ability to accumulate knowledge from our experiences. Although we use these two mental …

DNA methylation: a promising approach in management of Alzheimer's disease and other neurodegenerative disorders

G Kaur, SSS Rathod, MM Ghoneim, S Alshehri… - Biology, 2022 - mdpi.com
Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

[PDF][PDF] DNA methylation alterations in Alzheimer's disease

AS Yokoyama, JC Rutledge… - Environmental epigenetics, 2017 - academic.oup.com
The observation that Alzheimer's disease (AD) patients with similar and even identical
genetic backgrounds often present with heterogeneous pathologies has prompted the …

Dynamic regulation of DNA methylation and brain functions

J Xie, L Xie, H Wei, XJ Li, L Lin - Biology, 2023 - mdpi.com
Simple Summary DNA methylation is involved in biological processes including
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …

Epigenetics in Alzheimer's disease: a focus on DNA modifications

N Coppieters, M Dragunow - Current pharmaceutical design, 2011 - ingentaconnect.com
Epigenetic alterations have been associated with several human diseases including
Alzheimer's disease (AD). AD is a complex neurodegenerative disease characterized by a …