DNA methylation in the pathology of Alzheimer's disease: from gene to cognition
Alzheimer's disease (AD) is a debilitating disorder that manifests with amyloid beta plaque
deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although …
deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although …
Epigenetics in Alzheimer's disease: perspective of DNA methylation
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …
understood, but over the past years, the involvement of epigenetic mechanisms in the …
Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases
JAY Roubroeks, RG Smith… - Journal of …, 2017 - Wiley Online Library
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …
various neurodegenerative diseases. In this review, we discuss advances that have been …
Amyloid-β alters the DNA methylation status of cell-fate genes in an Alzheimer's disease model
N Taher, C McKenzie, R Garrett… - Journal of …, 2014 - content.iospress.com
Alzheimer's disease (AD) is characterized by neurofibrillary tangles and extracellular
amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding …
amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding …
Opening up the DNA methylome of dementia
R Delgado-Morales, M Esteller - Molecular psychiatry, 2017 - nature.com
Dementia is a complex clinical condition characterized by several cognitive impairments that
interfere with patient independence in executing everyday tasks. Various neurodegenerative …
interfere with patient independence in executing everyday tasks. Various neurodegenerative …
DNA methylation impacts on learning and memory in aging
L Liu, T van Groen, I Kadish, TO Tollefsbol - Neurobiology of aging, 2009 - Elsevier
Learning and memory are two of the fundamental cognitive functions that confer us the
ability to accumulate knowledge from our experiences. Although we use these two mental …
ability to accumulate knowledge from our experiences. Although we use these two mental …
DNA methylation: a promising approach in management of Alzheimer's disease and other neurodegenerative disorders
G Kaur, SSS Rathod, MM Ghoneim, S Alshehri… - Biology, 2022 - mdpi.com
Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …
corresponding gene expression. During the developmental stage, embryonic stem cells …
[PDF][PDF] DNA methylation alterations in Alzheimer's disease
AS Yokoyama, JC Rutledge… - Environmental epigenetics, 2017 - academic.oup.com
The observation that Alzheimer's disease (AD) patients with similar and even identical
genetic backgrounds often present with heterogeneous pathologies has prompted the …
genetic backgrounds often present with heterogeneous pathologies has prompted the …
Dynamic regulation of DNA methylation and brain functions
J Xie, L Xie, H Wei, XJ Li, L Lin - Biology, 2023 - mdpi.com
Simple Summary DNA methylation is involved in biological processes including
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …
Epigenetics in Alzheimer's disease: a focus on DNA modifications
N Coppieters, M Dragunow - Current pharmaceutical design, 2011 - ingentaconnect.com
Epigenetic alterations have been associated with several human diseases including
Alzheimer's disease (AD). AD is a complex neurodegenerative disease characterized by a …
Alzheimer's disease (AD). AD is a complex neurodegenerative disease characterized by a …
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