The methyl-CpG binding proteins (MBPs) interpret the methylation of DNA and its
components. The number of MBPs in the human body currently stands at 15, which are split …

DNA methylation and the machinery involved in epigenetic regulation are key elements in
the maintenance of cellular homeostasis. Epigenetic mechanisms are involved in embryonic …

Epigenetics is the study of the heritable changes on gene expression that are responsible
for the regulation of development and that have an impact on several diseases. However, it …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

Methyl-CpG binding domain (MBD) proteins have been shown to couple DNA methylation to
transcriptional repression. This biological property suggests a role for MBD proteins in the …

Cancer is characterised by DNA hypermethylation and gene silencing of CpG island-
associated promoters, including tumour-suppressor genes. The methyl-CpG-binding domain …

DNA methylation is an epigenetic modification that is implicated in transcriptional silencing.
It is becoming increasingly clear that both correct levels and proper interpretation of DNA …

Cytosine methylation in CpG dinucleotides is believed to be important in gene regulation,
and is generally associated with reduced levels of transcription. Methylation-mediated gene …

Methyl-CpG Binding Domain (MBD) proteins are thought to be key molecules in the
interpretation of DNA methylation signals leading to gene silencing through recruitment of …

DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …