Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein
J Sloan-Lancaster, W Zhang, J Presley… - The Journal of …, 1997 - rupress.org
To investigate the cellular dynamics of ZAP-70, we have studied the distribution and
regulation of its intracellular location using a ZAP-70 green fluorescent protein chimera …
regulation of its intracellular location using a ZAP-70 green fluorescent protein chimera …
Insight into the therapeutic aspects of 'Zeta-Chain Associated Protein Kinase 70 kDa'inhibitors: A review
Abstract Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70), a member of Syk family
(non-receptor protein tyrosine kinase family), has an imperative function in the immune cell …
(non-receptor protein tyrosine kinase family), has an imperative function in the immune cell …
ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic …
The zeta-associated protein of 70 kDa (ZAP-70) is expressed in patients with aggressive
chronic lymphocytic leukemia (CLL). We found that ZAP-70+ CLL cells expressed activated …
chronic lymphocytic leukemia (CLL). We found that ZAP-70+ CLL cells expressed activated …
[HTML][HTML] A cysteine residue within the kinase domain of Zap70 regulates Lck activity and proximal TCR signaling
A Schultz, M Schnurra, A El-Bizri, NM Woessner… - Cells, 2022 - mdpi.com
Alterations in both the expression and function of the non-receptor tyrosine kinase Zap70
are associated with numerous human diseases including immunodeficiency, autoimmunity …
are associated with numerous human diseases including immunodeficiency, autoimmunity …
ZAP70 expression enhances chemokine‐driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins
JM Laufer, R Lyck, DF Legler - The FASEB Journal, 2018 - Wiley Online Library
The ζ‐associated protein of 70 kDa (ZAP70) is expressed in the aggressive form of B‐cell
chronic lymphocytic leukemia (CLL). Moreover, the integrin very late antigen (VLA)‐1 is …
chronic lymphocytic leukemia (CLL). Moreover, the integrin very late antigen (VLA)‐1 is …
ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)
SJ Richardson, C Matthews, MA Catherwood… - Blood, 2006 - ashpublications.org
Molecular markers like IgVH mutational status, chromosomal abnormalities, and CD38 and
ZAP-70 expression have prognostic value in B-cell chronic lymphocytic leukemia (B-CLL) …
ZAP-70 expression have prognostic value in B-cell chronic lymphocytic leukemia (B-CLL) …
Immunohistochemical analysis of ZAP‐70 expression in B‐cell lymphoid neoplasms
ZAP‐70 is a tyrosine kinase that participates in early B‐cell differentiation and is a
prognostic factor in chronic lymphocytic leukaemia (CLL), where it is associated with an …
prognostic factor in chronic lymphocytic leukaemia (CLL), where it is associated with an …
Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome
ML Giardino Torchia, D Dutta… - Proceedings of the …, 2018 - National Acad Sciences
ZAP-70 is a tyrosine kinase that is essential for initiation of T cell antigen receptor (TCR)
signaling. We have found that T cell p38 MAP kinase (MAPK), which is directly …
signaling. We have found that T cell p38 MAP kinase (MAPK), which is directly …
[HTML][HTML] Adhesion of ZAP-70+ chronic lymphocytic leukemia cells to stromal cells is enhanced by cytokines and blocked by inhibitors of the PI3-kinase pathway
ST Lafarge, JB Johnston, SB Gibson, AJ Marshall - Leukemia research, 2014 - Elsevier
CLL cell survival and proliferation is enhanced through direct contact with supporting cells
present in lymphoid tissues. PI3Ks are critical signal transduction enzymes controlling B cell …
present in lymphoid tissues. PI3Ks are critical signal transduction enzymes controlling B cell …
[HTML][HTML] Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling
V Di Bartolo, D Mege, V Germain, M Pelosi… - Journal of Biological …, 1999 - ASBMB
Following T cell antigen receptor (TCR) engagement, the protein tyrosine kinase (PTK) ZAP-
70 is rapidly phosphorylated on several tyrosine residues, presumably by two mechanisms …
70 is rapidly phosphorylated on several tyrosine residues, presumably by two mechanisms …