Interleukin 4 (IL-4), an essential mediator of B cell development, plays a role in survival of
chronic lymphocytic leukemia (CLL) cells. To obtain new insights into the function of the IL-4 …

Abstract Zeta-associated protein-70 (ZAP70) expression measured by flow cytometry has
been proposed as a surrogate marker of the somatic mutation status of the immunoglobulin …

Establishing both central and peripheral tolerance requires the appropriate TCR signaling
strength to discriminate self‐from agonist‐peptide bound to self MHC molecules. ZAP70, a …

The crucial dependence of chronic lymphocytic leukemia (CLL) cells on signals derived from
the B cell receptor (BCR) has encouraged the development of new inhibitors, which interfere …

We identified a novel cDNA encoding truncated ZAP-70, which lacked the SH2 domain and
a part of interdomain B, and named it truncated ZAP kinase (TZK). TZK was expressed in the …

The expression of 70 kDa protein zeta-associated protein (ZAP-70) in chronic lymphocytic
leukemia (CLL) has been used to detect those patients with more aggressive disease. The …

The delivery of signals from the activated T cell antigen receptor (TCR) inside the cell relies
on the protein tyrosine kinase ZAP-70 (ζ-associated protein of 70 kDa). A recent crystal …

All series of events required for T cell development, activation, and differentiation are
regulated by signals that are generated by the engagement of the T cell receptor (TCR) 2 …

Lineage commitment and differentiation of hematopoietic cells takes place in well-defined
microenvironmental surroundings. Communication with other cell types is a vital prerequisite …

Lck and Zap70, two non-receptor tyrosine kinases, play a crucial role in the regulation of
membrane proximal TCR signaling critical for thymic selection, CD4/CD8 lineage choice …