Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …

Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

DNA methylation occurs on cytosines, is catalyzed by DNA methyltransferases (DNMTs),
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

ABSTRACT DNA methylation is a highly conserved epigenetic modification that plays
essential roles in mammalian gene regulation, genome stability and development. Despite …

The modification of DNA by methylation is an important epigenetic mechanism that affects
the spatial and temporal regulation of gene expression. Methylation patterns have been …

Previously published comparative functional genomic data sets from primates using frozen
tissue samples, including many data sets from our own group, were often collected and …