Cryptococcus neoformans Capsule Structure Evolution In Vitro and during Murine Infection

D Garcia-Hermoso, F Dromer, G Janbon - Infection and immunity, 2004 - Am Soc Microbiol
Cryptococcus neoformans capsule structure modifications after prolonged in vitro growth or
in vivo passaging have been reported previously. However, nothing is known about the …

Organ-Dependent Variation of Capsule Thickness inCryptococcus neoformans during Experimental Murine Infection

J Rivera, M Feldmesser, M Cammer… - Infection and …, 1998 - Am Soc Microbiol
In studies of murine infection, the capsule thickness of Cryptococcus neoformans varied
depending on the organ. The relative order of thickness was as follows: lung> brain> in vitro …

Phenotypic Switching in a Cryptococcus neoformans Variety gattii Strain Is Associated with Changes in Virulence and Promotes Dissemination to the Central …

N Jain, L Li, DC McFadden, U Banarjee… - Infection and …, 2006 - Am Soc Microbiol
This is the first report of a Cryptococcus neoformans var. gattii strain (serotype B) that
switches reversibly between its parent mucoid (NP1-MC) colony morphology and a smooth …

Similar evolutionary trajectories in an environmental Cryptococcus neoformans isolate after human and murine infection

P Sephton-Clark, SA McConnell… - Proceedings of the …, 2023 - National Acad Sciences
A pet cockatoo was the suspected source of Cryptococcus neoformans recovered from an
immunocompromised patient with cryptococcosis based on molecular analyses available in …

Pathogenesis of Cryptococcus neoformans is Associated with Quantitative Differences in Multiple Virulence Factors

R Blackstock, KL Buchanan, R Cherniak, TG Mitchell… - Mycopathologia, 1999 - Springer
Two isolates of Cryptococcus neoformans were previously described as being highly
divergent in their level of capsule synthesis in vivo and in their virulence for mice. The highly …

Most Environmental Isolates of Cryptococcus neoformans var. grubii (Serotype A) Are Not Lethal for Mice

AP Litvintseva, TG Mitchell - Infection and immunity, 2009 - Am Soc Microbiol
Most cases of cryptococcosis are caused by Cryptococcus neoformans var. grubii (serotype
A), which is widespread in the environment, where it is primarily associated with pigeon …

Microevolution of a Standard Strain ofCryptococcus neoformans Resulting in Differences in Virulence and Other Phenotypes

SP Franzot, J Mukherjee, R Cherniak… - Infection and …, 1998 - Am Soc Microbiol
Cryptococcus neoformans is a major fungal pathogen for patients with debilitated immune
systems. However, no information is available on the stability of virulence or of phenotypes …

Phenotypic Switching in Cryptococcus neoformansResults in Changes in Cellular Morphology and Glucuronoxylomannan Structure

BC Fries, DL Goldman, R Cherniak, R Ju… - Infection and …, 1999 - Am Soc Microbiol
Cryptococcus neoformans strains exhibit variability in their capsular polysaccharide, cell
morphology, karyotype, and virulence, but the relationship between these variables is poorly …

Congenic strains of the filamentous form of Cryptococcus neoformans for studies of fungal morphogenesis and virulence

B Zhai, P Zhu, D Foyle, S Upadhyay… - Infection and …, 2013 - Am Soc Microbiol
Cryptococcus neoformans is an unconventional dimorphic fungus that can grow either as a
yeast or in a filamentous form. To facilitate investigation of genetic factors important for its …

The Mouse Inhalation Model of Cryptococcus neoformans Infection Recapitulates Strain Virulence in Humans and Shows that Closely Related Strains Can Possess …

L Mukaremera, TR McDonald, JN Nielsen… - Infection and …, 2019 - Am Soc Microbiol
Cryptococcal meningitis (CM) causes high rates of HIV-related mortality, yet the
Cryptococcus factors influencing patient outcome are not well understood. Pathogen …